A determina\u00e7\u00e3o da actividade antioxidante\u00a0vs<\/i>\u00a0anticancer\u00edgena de compostos fen\u00f3licos de origem natural ou sint\u00e9tica \u00e9 actualmente um importante tema de investiga\u00e7\u00e3o na \u00e1rea das Ci\u00eancias Biol\u00f3gica e Bioqu\u00edmica.
\nDe facto, t\u00eam sido levados a cabo v\u00e1rios estudos com vista \u00e0 obten\u00e7\u00e3o de novos compostos para a preven\u00e7\u00e3o, tanto\u00a0in vitro<\/i>\u00a0como\u00a0in vivo<\/i>, de processos oxidativos prejudiciais. Os derivados fen\u00f3licos, como os \u00e1cidos benz\u00f3ico e cin\u00e2mico ou flavon\u00f3ides, t\u00eam sido frequentemente usados como modelos para o desenvolvimento deste tipo de compostos. Estudos recentes sobre a actividade biol\u00f3gica de \u00e1cidos fen\u00f3licos de origem natural permitiram concluir que os \u00e1cidos sin\u00e1pico, fer\u00falico e cafeico, tal como os seus an\u00e1logos (presentes na dieta em grandes quantidades) s\u00e3o agentes antioxidantes\/anticancer\u00edgenos muito promissores.
\nO presente projecto visa a s\u00edntese de v\u00e1rios \u00e1cidos cin\u00e2micos, e derivados, do baseados em modelos naturais, e a determina\u00e7\u00e3o das suas propriedades antioxidantes\u00a0vs<\/i>\u00a0anticancer\u00edgenas. A estrat\u00e9gia ser\u00e1 guiada atrav\u00e9s de um estudo, qualitativo e quantitativo, de Rela\u00e7\u00e3o Estrutura-Actividade (REA). Para os compostos mais promissores, pretendem-se ainda investigar os respectivos mecanismos de ac\u00e7\u00e3o.<\/p>\n
State<\/b>
\nFinished
\nPeriod<\/b>
\n2005 to 2008
\nFunding<\/b>
\n63.500,00 euros
\nProject code<\/b>
\nPOCI\/QUI\/55631\/2004
\nFunding Entity<\/b>
\nPortuguese Foundation for Science and Technology (FCT), Portugal<\/p>\n
Members<\/b> Publications<\/b> Phenolic Esters with Potential Anticancer Activity – The Structural Variable<\/a> Ab Initio<\/em> and Density Functional Study of a Caffeic Acid Amide\u00a0<\/a> New Insights on the Anticancer Properties of Dietary Polyphenols<\/a> Cytotoxic and COX-2 Inhibition Properties of Hydroxycinnamic Derivatives<\/a> \u03b2-Nitrostyrene Derivatives as Potential Antibacterial Agents: A Structure-Property-Activity Relationship Study<\/a> Conformational Analysis of the Potential Anticancer Agent Ethyl Trihydroxycinnamate \u2013 A Combined Raman Spectroscopy and Ab Initio Study<\/a> Potentiometric studies on the complexation of copper (II) by phenolic acids as ligand models of humic substances<\/a> Simple Coumarins and Analogues in Medicinal Chemistry. Ocurrence, Synthesis, and Biological Activity<\/a> Correlation between the antioxidant activity against lipoperoxidation of polyphenolic compounds and their partition coefficients in a liposome\/buffer media Structure-Property Studies on the Antioxidant Activity of Flavonoids Present in the Diet<\/a> Phenolic Acid Derivatives with Potential Anticancer Properties \u2013 A Structure-Activity Relationship Study. Part 1: Methyl, Propyl and Octyl Esters of Caffeic and Gallic Acids<\/a> Identification of Synthetic Precursors of Amphetamine-like Drugs based on Raman Spectroscopy and ab Initio Calculations: \u03b2-Methyl-\u03b2-nitrostyrene Derivatives<\/a> Conformational Analysis of a Trihydroxylated Derivative of Cinnamic Acid \u2013 A Combined Raman Spectroscopy and Ab Initio Study<\/a> \u03b2-Nitrostyrene Derivatives – A Conformational Study by Combined Raman Spectroscopy and Ab Initio MO Calculations<\/a>
\nMaria Paula Matos Marques Catarro<\/a>\u00a0(Principal Investigator)
\nMaria Fernanda Martins Borges
\nLu\u00eds Alberto Esteves Batista de Carvalho<\/a>
\nAna Margarida Amado Roque Batista<\/a>
\nRita Figueiredo Moutinho Calheiros Cruz
\nFrancisco Paulo S\u00e1 de Campos Gil
\nNuno Jorge da Silva Pereira Milhazes
\nAna Maria Matos Beja
\nNuno Miguel Penacho Pereira
\nPaulo Jorge Oliveira
\nAna Maria Brett
\nMaria Jo\u00e3o Sottomayor
\nElisi\u00e1rio Jose Tavares Silva
\nFernanda Maria Fernandes Roleira
\nJorge Manuel Pinto Jesus Garrido
\nErmelinda Manuela Pinto Jesus Garrido
\nCarmen Diniz Pereira
\nPaula Maria Fa\u00e7anha Cruz Fresco
\nMaria Nat\u00e1lia Dias Soeiro Cordeiro<\/p>\n
\nAntioxidant Phenolic Esters with Potential Anticancer Activity: A Raman Spectroscopy Study<\/a>
\nR. Calheiros, N.F.L. Machado, S.M. Fiuza, A. Gaspar, J. Garrido, N. Milhazes, F. Borges, M.P.M. Marques
\nJournal of Raman Spectroscopy\u00a039<\/b>, 95-107 (2008)<\/p>\n
\nN.F.L. Machado, R. Calheiros, S.M. Fiuza, F. Borges, A. Gaspar, J. Garrido, M.P.M Marques
\nJournal of Molecular Modeling\u00a013<\/b>, 865-877 (2007)<\/p>\n
\nDavid A. Rinc\u00f3n D, E.E. Daza C, M.N.D.S. Cordeiro
\nJournal of Molecular Structure (THEOCHEM)\u00a0804<\/b>, 57-63 (2007)<\/p>\n
\nP. Fresco, F. Borges, C. Diniz, M.P.M. Marques
\nMedicinal Research Reviews\u00a026<\/b>, 747-766 (2006)<\/p>\n
\nM.P.M. Marques, F. Borges, J. Sousa, R. Calheiros, J. Garrido, A. Gaspar, F. Antunes, C. Diniz, P. Fresco
\nLetters in Drugs Design & Discovery\u00a03<\/b>, 316-320 (2006)<\/p>\n
\nN. Milhazes, R. Calheiros, M.P.M. Marques, J. Garrido, M.N.D.S. Cordeiro, C. Rodrigues, S. Quinteira, C. Novais, L. Peixe, F. Borges
\nBioorganic & Medicinal Chemistry\u00a014<\/b>, 4078-4088 (2006)<\/p>\n
\nJ.B. Sousa, R. Calheiros, V. Rio, F. Borges, M.P.M. Marques
\nJournal of Molecular Structure\u00a0783<\/b>, 122-135 (2006)<\/p>\n
\nF. Borges, C. Guimar\u00e3es, J.L.F.C. Lima, I. Pinto, S. Reis
\nTalanta\u00a066<\/b>, 670-673 (2005)<\/p>\n
\nF. Roleira, N. Milhazes, F. Borges, L. Santana,\u00a0 E. Uriarte
\nCurrent Medicinal Chemistry\u00a012\u00a0<\/b>, 887-916 (2005)<\/p>\n
\nS. Reis, C. Siquet, V. Rio, F. Borges, J.L.F.C. Lima
\nRevista Portuguesa de Farm\u00e1cia\u00a0LII(2)<\/b>, 13-14 (2005)<\/p>\n
\nS. Teixeira, C. Siquet, C. Alves, I. Boal, M.P.M. Marques, F. Borges, J.L.F.C. Lima, S. Reis
\nFree Radicals in Biology & Medicine\u00a039<\/b>, 1099-1108 (2005)<\/p>\n
\nS.M. Fiuza, C.A. Gomes, L.J. Teixeira, T. Gir\u00e3o da Cruz, M.N. Cordeiro, N. Milhazes, F. Borges, M.P.M. Marques
\nBioorganic & Medicinal Chemistry\u00a012<\/b>, 3581-3589 (2004)<\/p>\n
\nN. Milhazes, F. Borges, R. Calheiros\u00a0 M.P.M. Marques
\nThe Analyst\u00a0129<\/b>, 1106-1117 (2004)<\/p>\n
\nS.M. Fiuza, E. Van Besien, N. Milhazes, F. Borges and M.P.M. Marques
\nJournal of Molecular Structure\u00a0693<\/b>, 103-118 (2004)<\/p>\n
\nR. Calheiros, N. Milhazes, F. Borges, M.P.M. Marques
\nJournal of Molecular Structure\u00a0692<\/b>, 91-106 (2004)<\/p>\n