Melanoma is the most aggressive and lethal form of skin cancer, with a steadily increasing incidence in the last decades. Early melanomas (melanomas in situ) can be successfully excised, which results in a high cure rate (5-year survival rate of 97%). However, for the more advanced stages the mortality rate is high. Clinical diagnosis of early-stage melanoma is notoriously difficult for dermatologists, often leading to missed diagnosis as well as to unnecessary removal of benign lesions. Dermatologists report a strong clinical need of an add-on tool that will enable to differentiate melanoma from suspicious melanocytic lesions. A promising approach is an analysis based on biochemical differences, which are much more specific than morphological variations (and usually precede the latter).
Raman spectroscopy (RS) is a highly-sensitive optical technique based on specific molecular vibrations of the tissue components, which enables non-invasive and non-destructive monitoring of tissue, revealing disease-prompted variations and allowing to differentiate healthy from malignant samples with high sensitivity and specificity.
The present proposal is predicated on developing a high-speed low-cost RS solution for an objective diagnosis of melanoma, which is an unmet clinical need. The success of this study is ensured by the expertise of the team members in a close scientific collaboration between 2 R&D national laboratories (QFM-UC, LIBPhys-UC), 2 consulting R&D laboratories (University of Nottingham, Erasmus Medical Centre), and two health-care institutions in the area of oncology and melanoma (IPOCFG and LUMC).<\/p>\n
State<\/b>
Finished
Period<\/b>
2023 to 2024
Funding<\/b>
49.944,86 \u20ac
Project code<\/b>
2022.03336.PTDC
Funding entity<\/b>
Portuguese Foundation for Science and Technology (FCT)<\/p>\n
Members<\/b> Melanoma is the most aggressive and lethal form of skin cancer, with a steadily increasing incidence in the last decades. Early melanomas (melanomas in situ) can be successfully excised, which results in a high cure rate (5-year survival rate of 97%). However, for the more advanced stages the mortality rate is high. Clinical diagnosis of […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":596,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2149","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/pages\/2149","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/comments?post=2149"}],"version-history":[{"count":3,"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/pages\/2149\/revisions"}],"predecessor-version":[{"id":4845,"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/pages\/2149\/revisions\/4845"}],"up":[{"embeddable":true,"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/pages\/596"}],"wp:attachment":[{"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/media?parent=2149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Lu\u00eds Alberto Esteves Batista de Carvalho<\/a> (Principal Investigator)
Maria Paula Matos Marques Catarro<\/a>
Ana L\u00facia Marques Batista de Carvalho<\/a> \u00a0
Adriana Maria Pires Mamede<\/a>
Andreia Sofia Feitor Gaud\u00eancio
Francisco Paulo de S\u00e1 Campos Gil
Jo\u00e3o Manuel Cardoso
Maria Miguel Camelo Amaral Canelas
Miguel Silva
Paulo Figueiredo
Pedro Guilherme da Cunha Leit\u00e3o Dias Vaz<\/p>\n","protected":false},"excerpt":{"rendered":"