{"id":541,"date":"2017-08-23T19:56:18","date_gmt":"2017-08-23T19:56:18","guid":{"rendered":"http:\/\/qfm.uc.pt\/?page_id=541"},"modified":"2026-01-16T15:27:19","modified_gmt":"2026-01-16T15:27:19","slug":"anabatistacarvalho","status":"publish","type":"page","link":"https:\/\/qfm.uc.pt\/index.html\/language\/en\/anabatistacarvalho\/","title":{"rendered":"Ana Batista de Carvalho"},"content":{"rendered":"

\"\"<\/p>\n

Ana Batista de Carvalho <\/b>completed her PhD in Biosciences 2017 by University of Coimbra her Master in Biochemistry in 2010 by University of Coimbra with her Master Thesis being developed at Universita degli Studi di Roma La Sapienza Dipartimento di Scienze Biochimiche Alessandro Rossi Fanelli. Presently she is a Junior Researcher at Unidade de I&D Qu\u00edmica-F\u00edsica Molecular of the University of Coimbra. She has published 28 articles in journals with peer review with a total of 195 citations and H-index of 9 (search done by author Batista de Carvalho, A.L.M.). Supervised or co-supervised several MSc and BSc students. She is presently co-supervisor of 1 PhD student. She participated in 3 projects and is presently a member of the funded R&D Project VIBSonCANCER\/Centro-01-0145-FEDER-029956. She is an Associated member of the Royal Society of Chemistry (RSC), belongs to the Clinical Infrared and Raman Spectroscopy for Medical Diagnosis (CLIRSPEC) as well as to the Portuguese Society of Biochemistry (SPB). She has expertise in applying vibrational spectroscopy (FTIR (either benchtop or Syncrothron radiation), Raman and with neutrons) to the study of biological samples such as human cells and tissues. Currently, her research is centred on the identification, using vibrational spectroscopy, of early liver rejection biomarkers in liver biopsies. She is also enrolled in the design of Pt\/Pd-based anticancer agents.<\/p>\n

\n\n\n\n
Address<\/b>
\nDepartamento de Qu\u00edmica
\nFaculdade de Ci\u00eancias e Tecnologia
\nUniversidade de Coimbra
\n3004-535 Coimbra<\/td>\n		E-mail<\/b>
\nalmbc@uc.pt<\/a>
\nTelephone<\/b>
\n+351 239 852 084<\/td>\n		ORCID ID<\/a>
\nResearcherID<\/a>
\nScopus ID<\/a>
\nResearchGate<\/a>
\nCi\u00eancia Vitae<\/a>
\nLinkedIn<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

Publications<\/b><\/p>\n

Probing Drug Pharmacokinetics Using Neutron Scattering Techniques\u00a0<\/a>
\nC.B. Martins, M. Sarter, A.L.M. Batista de Carvalho, V. Garc\u00eda-Sakai, T. Seydel, J. Ollivier, L.A.E. Batista de Carvalho, M.P. Marques
\nRoyal Society of Chemistry,28<\/strong>,1293 (2026)<\/p>\n

New Chemotherapeutic Approaches to Treatment of Mesenchymal Triple-Negative Breast Cancer-Sensitive and Resistant to Cisplatin: Assessment of Cellular Response by Vibrational Microspectroscopy<\/a>
\nC.B. Martins, A.L.M. Batista de Carvalho, M.M. F\u00e9lix, M. Vojtek, C. Diniz, L.A.E. Batista de Carvalho, M.P.M. Marques
\nAnalytical Chemistry,\u00a097(27), <\/strong>14709-14721 (2025)<\/p>\n

Synchrotron Nano-FTIR Spectroscopy for Probing Anticancer Drugs at Subcellular Scale<\/a>
\nL.A.E. Batista de Carvalho, G. Cinque, A.L.M. Batista de Carvalho, J.Marques, M.D.Fogley, H. Vondracek, M.P.M. Marques
\nScientific Reports 14<\/strong>, 17166 (2024)<\/p>\n

Vibrational microspectroscopy as a tool to unveil new chemotherapeutic strategies against osteosarcoma<\/a>
\nR.C. Laginha, J.D. Silva, G. Cinque, L.A.E. Batista de Carvalho, A.L.M. Batista de Carvalho
\nSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (2024)<\/p>\n

Pd2<\/sub>Spermine as an Alternative Therapeutics for Cisplatin-Resistant Triple-Negative Breast Cancer<\/a>
\nT.J. Carneiro, A.L.M. Batista de Carvalho, M. Vojtek, R.C. Laginha, M.P.M. Marques, C. Diniz, A.M. Gil
\nJournal of Medicinal Chemistry (2024)<\/p>\n

Cervical Squamous Cell Carcinoma Diagnosis by FTIR Microspectroscopy<\/a>
\nM.M. F\u00e9lix, M.V. Tavares, I.P. Santos, A.L.M. Batista de Carvalho, L.A.E. Batista de Carvalho, M.P.M. Marques
\nMolecules 29<\/strong>, 922 (2024)<\/p>\n

Cellular Dynamics as a Marker of Normal-to-Cancer Transition in Human Cells<\/a>
\nM.P.M. Marques, A.L.M. Batista de Carvalho, C.B. Martins, J.D. Silva, M. Sarter, V. Garc\u00eda Sakai, R. Stewart, L.A.E. Batista de Carvalho
\nScientific Reports 13<\/strong>, 21709 (2023)<\/p>\n

Disclosing a Metabolic Signature of Cisplatin Resistance in MDA-MB-231 Triple-Negative Breast Cancer Cells by NMR Metabolomics<\/a>
\nT.J. Carneiro, A.L.M. Batista de Carvalho, M. Vojtek, I.F. Carmo, M.P.M. Marques, C. Diniz, A.M. Gil
\nCancer Cell International 23<\/strong>, 310 (2023)<\/p>\n

Fluorinated Mn(III)\/(II)-Porphyrin with Redox-Responsive 1<\/sup>H and 19<\/sup>F Relaxation Properties<\/a>
\nS.M.A. Pinto, A.R.R. Ferreira, D.S.S. Teixeira, S.C.C. Nunes, A.L.M. Batista de Carvalho, J.M.S. Almeida, Z. Garda, A. Pallier, A.A.C.C. Pais, C.M.A. Brett, E. T\u00f3th, M.P.M. Marques, M.M. Pereira, C.F.G.C. Geraldes
\nChemistry \u2013 A European Journal 2023<\/strong>, e202301442 (2023)<\/p>\n

Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Activity Towards TNBC-sensitive and -resistant to Cisplatin<\/a>
\nM. Vojtek, C.B. Martins, R. Ramos, S.G. Duarte, I.M.P.L.V.O. Ferreira, A.L.M. Batista de Carvalho, M.P.M. Marques, C. Diniz
\nPharmaceutics \u2013 Special Issue “Beyond the Platinum in Metal-Based Cancer Therapy II” 15<\/strong>, 1205\u00a0(2023)<\/p>\n

A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line<\/a>
\nJ.D. Silva, J. Marques, I.P. Santos, A.L.M. Batista de Carvalho, C.B. Martins, R.C. Laginha, L.A.E. Batista de Carvalho, M.P.M. Marques
\nMolecules 28(4)<\/strong>, 1698 (2023)<\/p>\n

Evaluation of the Cytotoxic Effect of Pd2<\/sub>Spm against Prostate Cancer through Vibrational Microspectroscopies<\/a>
\nR.C. Laginha, C.B. Martins, A.L.C. Brand\u00e3o, J. Marques, M.P.M. Marques, L.A.E. Batista de Carvalho, I.P. Santos, A.L.M. Batista de Carvalho
\nInternational Journal of Molecular Sciences 24(3)<\/strong>, 1888 (2023)<\/p>\n

Effect of Pd2<\/sub>Spermine on Mice Brain-Liver Axis Metabolism Assessed by NMR Metabolomics<\/a>
\nT.J. Carneiro, M. Vojtek, S. Gon\u00e7alves-Martins, A.L.M. Batista de Carvalho, M.P.M. Marques, C. Diniz, A.M. Gil
\nInternational Journal of Molecular Sciences 23(22)<\/strong>, 13773 (2022)<\/p>\n

Breast Cancer or Surrounding Normal Tissue? A Successful Discrimination by FTIR and Raman Microspectroscopies<\/a>
\nA.P. Mamede, I.P. Santos, A.L.M. Batista de Carvalho, P. Figueiredo, M.C. Silva, M.P.M. Marques, L.A.E. Batista de Carvalho
\nAnalyst 147(21)<\/strong>, 4919\u20134932 (2022)<\/p>\n

Water Dynamics in Human Cancer and Non-Cancer Tissues<\/a>
\nM.P.M. Marques, I.P. Santos, A.L.M. Batista de Carvalho, A.P. Mamede, C.B. Martins, P. Figueiredo, M. Sarter, V. Garcia Sakai, L.A.E. Batista de Carvalho
\nPhysical Chemistry Chemical Physics 24(25)<\/strong>, 15406\u201315415 (2022)<\/p>\n

The Role of Hidden Conformers in Determination of Conformational Preferences of Mefenamic Acid by NOESY Spectroscopy<\/a>
\nK.V. Belov, L.A.E. Batista de Carvalho, A.A. Dyshin, S.V. Efimov, I.A. Khodov
\nSpectroscopy Pharmaceutics 14(11)<\/strong>, 2276 (2022)<\/p>\n

Metabolic Impact of Anticancer Drugs Pd2<\/sub>Spermine and Cisplatin on the Brain of Healthy Mice<\/a>
\nT.J. Carneiro, M. Vojtek, S. Gon\u00e7alves-Monteiro, J.R. Neves, A.L.M. Batista de Carvalho, M.P.M. Marques, C. Diniz, A.M. Gil
\nPharmaceutics 14(2)<\/strong>, 259 (2022)<\/p>\n

Pd2<\/sub>Spermine Complex Shows Cancer Selectivity and Efficacy to Inhibit Growth of Triple-Negative Breast Tumors in Mice<\/a>
\nM. Vojtek, S. Gon\u00e7alves-Monteiro, P. Seminska, K. Valova, L. Bell\u00f3n, P. Dias-Pereira, F. Marques, M.P.M. Marques, A.L.M. Batista de Carvalho, H. Mota-Filipe, I.M.P.L.V.O. Ferreira, C. Diniz
\nBiomedicines 10(2)<\/strong>, 210 (2022)<\/p>\n

Who\u2019s who? Discrimination of Human Breast Cancer Cell Lines by Raman and FTIR Microspectroscopy<\/a>
\nI.P. Santos, C.B. Martins, L.A.E. Batista de Carvalho, M.P.M. Marques, A.L.M. Batista de Carvalho
\nCancers \u2013 Special Issue Biophotonics and Imaging for Cancer Screening, Diagnosis, and Treatment Monitoring 14(2)<\/strong>, 452 (2022)<\/p>\n

Palladium-Spermine Complex (Pd2<\/sub>Spm) Triggers Autophagy and Caspase-Independent Cell Death in Triple-Negative Breast Cancer Cells<\/a>
\nM. Vojtek, M.P.M. Marques, A.L.M. Batista de Carvalho, H. Mota-Filipe, I.M. Ferreira, C. Diniz
\nCancer Cells. In Medical Sciences Forum 14(1)<\/strong>, 142 (2022)<\/p>\n

A New Look into Cancer \u2013 A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance<\/a>
\nA.P. Mamede, I.P. Santos, A.L.M. Batista de Carvalho, P. Figueiredo, M.C. Silva, M.V. Tavares, M.P.M. Marques, L.A.E. Batista de Carvalho
\nCancers \u2013 Special Issue Biophotonics and Imaging for Cancer Screening, Diagnosis, and Treatment Monitoring, 13(21)<\/strong>, 5336 (2021)<\/p>\n

Novel Insights into Mice Multi-organ Metabolism upon Exposure to a Potential Anticancer Pd(II)-Agent<\/a>
\nT.J. Carneiro, R. Ara\u00fajo, M. Vojtek, S. Gon\u00e7alves-Monteiro, C. Diniz, A.L.M. Batista de Carvalho, M.P.M. Marques, A.M. Gil
\nMetabolites- Special Issue \u2013 Metabolomics in Drug Discovery and Development 11(2)<\/strong>, 114 (2021)<\/p>\n

Preclinical Pharmacokinetics and Biodistribution of Anticancer Dinuclear Palladium(II)-Spermine Complex (Pd2<\/sub>Spm) in Mice<\/a>
\nM. Vojtek, S. Gon\u00e7alves-Monteiro, E. Pinto, S. Kalivodov\u00e1, A. Almeida, M.P.M. Marques, A.L.M. Batista de Carvalho, C.B. Martins, H. Mota-Filipe, I.M.P.L.V.O Ferreira, C. Diniz
\nPharmaceuticals 14(2)<\/strong>, 173 (2021)<\/p>\n

Metallodrug\u2013Protein Interaction Probed by Synchrotron Terahertz and Neutron Scattering Spectroscopy<\/a>
\nL.A.E. Batista de Carvalho, A.P. Mamede, A.L.M. Batista de Carvalho, J. Marques, G. Cinque, S. Rudi\u0107, M.P.M. Marques
\nBiophysical Journal 120(15)<\/strong>, 3070\u20133078 (2021)<\/p>\n

Response of Osteosarcoma Cell Metabolism to Platinum and Palladium Chelates as Potential New Drugs<\/a>
\nA.S. Martins, A.L.M. Batista de Carvalho, M.P.M. Marques, A.M. Gil
\nMolecules 26(16)<\/strong>, 4805 (2021)<\/p>\n

Re-use of Caco-2 Monolayers in Permeability Assays \u2013 Validation Regarding Cell Monolayer Integrity<\/a>
\nC.L. Pires, C. Pra\u00e7a, P.A.T. Martins, A.L.M. Batista de Carvalho, L. Ferreira, M.P.M. Marques, M.J. Moreno
\nPharmaceutics 13(10)<\/strong>, 1563 (2021)<\/p>\n

Impact of Pd2<\/sub>Spm(spermine) Complex on the Metabolism of Triple-negative Breast Cancer Tumors of a Xenograft Mouse Model<\/a>
\nT.J. Carneiro, R. Ara\u00fajo, M. Vojtek, S.G. Monteiro, C. Diniz, A.L.M. Batista de Carvalho, M.P.M. Marques, A.M. Gil
\nInternational Journal of Molecular Sciences 22(19)<\/strong>, 10775 (2021)<\/p>\n

Intracellular Water as a Mediator of Anticancer Drug Action<\/a>
\nM.P.M. Marques, A.L.M. Batista de Carvalho, A.P Mamede, S. Rudic, A. Dopplapudi, V. Garc\u00eda Sakai, L.A.E. Batista de Carvalho
\nInternational Reviews in Physical Chemistry 39(1)<\/strong>, 67\u201381 (2020)<\/p>\n

Role of intracellular water in the normal-to-cancer transition in human cells \u2013 insights from quasi-elastic neutron scattering<\/a>
\nM.P.M. Marques, A.L.M. Batista de Carvalho, A.P. Mamede, A. Dopplapudi, V. Garc\u00eda Sakai, L.A.E. Batista de Carvalho
\nStructural Dynamics 7(5)<\/strong>, 054701 (2020)<\/p>\n

A New Look into the Mode of Action of Metal-Based Anticancer Drugs<\/a>
\nM.P.M. Marques, A.L.M. Batista de Carvalho, A.P. Mamede, A. Dopplapudi, S. Rudi\u0107, M. Tyagi, V. Garc\u00eda Sakai, L.A.E. Batista de Carvalho
\nMolecules 25(2)<\/strong>, 246 (2020)<\/p>\n

Cytotoxicity of Platinum and Palladium Chelates Against Osteosarcoma<\/a>
\nA.S. Martins, A.L.M. Batista de Carvalho, I. Lamego, M.P.M. Marques, A.M. Gil
\nChemistrySelect 5(20)<\/strong>, 5993\u20136000 (2020)<\/p>\n

Multi-organ NMR Metabolomics to Assess In Vivo Overall Metabolic Impact of Cisplatin in Mice<\/a>
\nT.J. Carneiro, R. Ara\u00fajo, M. Vojtek, S. Gon\u00e7alves-Monteiro, C. Diniz, A.L.M. Batista de Carvalho, M. P.M. Marques, Ana M. Gil
\nMetabolites 9(11)<\/strong>, 279 (2019)<\/p>\n

Chemotherapeutic Targets in Osteosarcoma Insights from Synchrotron-MicroFTIR and Quasi-Elastic Neutron Scattering<\/a>
\nM.P.M. Marques, A.L.M. Batista de Carvalho, A.P. Mamede, I.P. Santos, V. Garc\u00eda-Sakai, A. Dopplapudi, G. Cinque, M. Wolna, P. Gardner, L.A.E. Batista de Carvalho
\nThe Journal of Physical Chemistry B 123<\/strong>, 6968\u20136979 (2019)<\/p>\n

Bioinspired-Metalloporphyrin Magnetic Nanocomposite as a Reusable Catalyst for Synthesis of Diastereomeric (-)-isopulegol Epoxide. Anticancer Activity Against Human Osteosarcoma Cells (MG-63)<\/a>
\nL.D. Dias, A.L.M. Batista de Carvalho, S.M.A. Pinto, G.L.B. Aquino, M.J.F. Calvete, L.M. Rossi, M.P.M. Marques, M.M. Pereira
\nMolecules 24(1)<\/strong>, 52 (2019)<\/p>\n

Anticancer Drug Impact on DNA \u2013 A Study by Neutron Spectroscopy coupled to Synchrotron-based FTIR and EXAFS<\/a>
\nA.L.M. Batista de Carvalho, A.P. Mamede, A. Dopplapudi, V. Garcia Sakai, J. Doherty, M. Frogley, G. Cinque, P. Gardner, D. Gianolio, L.A.E. Batista de Carvalho, M.P.M. Marques
\nPhysical chemistry Chemical Physics 21(8)<\/strong>, 4162\u20134175 (2019)<\/p>\n

A Novel Approach in Glioblastoma Multiforme Drug Discovery: Perturbation Studies in Vitro<\/em><\/a>
\nL.C. Oliveira, M.P.M. Marques, A.J. Caseiro, S. R. Raposelli, A.L.M. Batista de Carvalho, A.P. Fonseca
\nJournal of Applied Pharmaceutical Science 9(4)<\/strong>, 58\u201365 (2019)<\/p>\n

The Impact of Antioxidants from the Diet on Breast Cancer Cells Monitored by Raman Microspectroscopy<\/a>
\nP.S.C. Medeiros, A.L.M. Batista de Carvalho, C. Ruano, J.C. Otero, M.P.M. Marques
\nLetters in Drug Design & Discovery 16(2)<\/strong>, 127\u2013137 (2018)<\/p>\n

Novel Platinum-based Anticancer Drug: a Complete Vibrational Study<\/a>
\nA.L.M. Batista de Carvalho, S.F. Parker, L.A.E Batista de Carvalho, M.P.M. Marques
\nActa Chrystallographica Section C \u2013 Structural Chemistry C74, 628\u2013634 (2018)<\/p>\n

Antiproliferative Activity of Olive Oil Phenolics Against Human Melanoma Cells<\/a>
\nA.L.M. Batista de Carvalho, F. Caselli, V. Rodrigues, F. Paiva-Martins, M.P.M. Marques
\nLetters in Drug Design & Discovery 14<\/strong>, 1\u20137 (2017)<\/p>\n

Intracellular Water \u2013 an Overlooked Drug Target? Cisplatin\u00b4s Impact in Cancer Cells Probed by Neutrons<\/a>
\nM.P.M. Marques, A.L.M. Batista de Carvalho, V. Garcia-Sakai, L. Hatter, L.A.E. Batista de Carvalho
\nPhysical Chemistry Chemical Physics\u00a019<\/b>, 2702\u20132713 (2017)<\/p>\n

Anti-invasive and Anti-proliferative Synergism Between Docetaxel and a Polynuclear Pd-Spermine Agent<\/a>
\nA.L.M. Batista de Carvalho, P.S.C. Medeiros, F.M. Costa, V.P. Ribeiro, J.B. Sousa, C. Diniz, M.P.M. Marques
\nPLoS ONE 11<\/strong>, e0167218 (2016)<\/p>\n

Raman Microspectroscopy for Probing the Impact of a Dietary Antioxidant on Human Breast Cancer Cells<\/a>
\nP.S.C. Medeiros, A.L.M. Batista de Carvalho, C. Ruano, J.C. Otero, M.P.M. Marques
\nFood&Function 7<\/strong>, 2800\u20132810 (2016)<\/p>\n

Chemotherapeutic Response to Cisplatin-like Drugs in Human Breast Cancer Cells Probed by Vibrational Microspectroscopy<\/a>
\nA.L.M. Batista de Carvalho, M. Pilling, P. Gardner, J. Doherty, G. Cinque, K. Wehbe, C. Kelley, L.A.E. Batista de Carvalho, M.P.M. Marques
\nFaraday Discussions 187<\/strong>, 273\u2013298 (2016)<\/p>\n

In Vitro Probing of Human Refractory Prostate Cancer Cells by MicroRaman Spectroscopy
\nA.L.M. Batista de Carvalho, C.R. Frias, J.C. Otero, M.P.M. Marques
\nFEBS Journal\u00a0280(S1)<\/b>, 311 (2013)<\/p>\n

New Strategies Against Prostate Cancer \u2013 Pt(II)-Based Chemotherapy<\/a>
\nC.S. Matos, A.L.M. Batista de Carvalho, R. Pedro Lopes, M.P.M. Marques
\nCurrent Medicinal Chemistry 19(27)<\/strong>, 4678\u20134687 (2012)<\/p>\n

Pt(II) Complexes with Linear Diamines \u2014 Part I: Vibrational Study of Pt-Diaminopropane<\/a>
\nA.L.M. Batista de Carvalho, S.M. Fiuza, J. Tomkinson, L.A.E. Batista de Carvalho, M.P.M. Marques
\nSpectroscopy: An International Journal\u00a027(5-6)<\/b>, 403\u2013413 (2012)<\/p>\n","protected":false},"excerpt":{"rendered":"

Ana Batista de Carvalho completed her PhD in Biosciences 2017 by University of Coimbra her Master in Biochemistry in 2010 by University of Coimbra with her Master Thesis being developed at Universita degli Studi di Roma La Sapienza Dipartimento di Scienze Biochimiche Alessandro Rossi Fanelli. Presently she is a Junior Researcher at Unidade de I&D […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-541","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/pages\/541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/comments?post=541"}],"version-history":[{"count":21,"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/pages\/541\/revisions"}],"predecessor-version":[{"id":4811,"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/pages\/541\/revisions\/4811"}],"wp:attachment":[{"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/media?parent=541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}