{"id":545,"date":"2017-08-23T19:56:50","date_gmt":"2017-08-23T19:56:50","guid":{"rendered":"http:\/\/qfm.uc.pt\/?page_id=545"},"modified":"2025-07-16T08:17:16","modified_gmt":"2025-07-16T08:17:16","slug":"ana-margarida-urbano","status":"publish","type":"page","link":"https:\/\/qfm.uc.pt\/index.html\/language\/en\/ana-margarida-urbano\/","title":{"rendered":"Ana Margarida Urbano"},"content":{"rendered":"

\"\"<\/p>\n

Ana Margarida Urbano <\/b>received a PhD in Biochemistry from the Universiy of Cambridge, UK. She is an assistant professor at the Department of Life Sciences of the\u00a0University of Coimbra, Portugal. Her main research interests are bioenergetics, oncometabolism and inorganic biochemistry and she is currently investigating the molecular basis of Cr(VI)-induced carcinogenesis.<\/p>\n

\n\n\n\n
Address<\/b>
\nDepartamento de Ci\u00eancias da Vida
\nFaculdade de Ci\u00eancias e Tecnologia
\nUniversidade de Coimbra
\nCal\u00e7ada Martim de Freitas
\n3000-456 Coimbra<\/td>\n		E-mail<\/b>
\namurbano@uc.pt<\/a>
\nTelephone<\/b>
\n+351 239 240 707<\/td>\n		ORCID ID<\/a>
\nResearcherID<\/a>
\nScopus ID<\/a>
\nCi\u00eancia Vitae<\/a>
\nLinkedIn<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

Publications<\/b><\/p>\n

Special issue – Mitochrondria in aging, cancer and cell death<\/a>
\nA.M. Urbano, P. J. Oliveira
\nBiochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, 167954 (2025)<\/p>\n

Mitochondrial Classic Metabolism and Its Often-underappreciated Facets<\/a>
\nJ.P. Moura, P.J. Oliveira, A.M. Urbano
\nBiochimica et Biophysica Acta (BBA) – Molecular Basis of Disease 1871 (6)<\/strong>, 167839 (2025)<\/p>\n

Two Targets, One Mission: Heterobivalent Metal-Based Radiopharmaceuticals for Prostate Cancer Imaging and Therapy<\/a>
\nM.C. Sobral. S.I. Mota, P.J. Oliveira, A.M. Urbano, A. Paulo
\nChemMedChem, e202500128 (2025)<\/p>\n

Mitochondria: An Overview of Their Origin, Genome, Architecture, and Dynamics<\/a>
\nJ.P. Moura, P.J. Oliveira, A.M. Urbano
\nBiochimica et Biophysica Acta (BBA) – Molecular Basis of Disease 1871 (5)<\/strong>, 167803 (2025)<\/p>\n

Polyhexanide-Releasing Membranes for Antimicrobial Wound Dressings: A Critical Review<\/a>
\nA.J. Guiomar, A.M. Urbano
\nMembranes 12(12)<\/strong>, 1281 (2022)<\/p>\n

Effect of exercise-conditioned human serum on the viability of cancer cell cultures: a systematic review and meta-analysis<\/a>
\nC.M. Soares, A.M. Teixeira, H. Sarmento, F.M. Silva, M.C. Rusenhack, M. Furmann, P.R. Nobre, M.A. Fachada, A.M. Urbano, J.P. Ferreira
\nExercise Immunology Review 27<\/strong>, 24\u201341 (2021)<\/p>\n

Oncometabolism: The switchboard of cancer \u2013 An editorial<\/a>
\nP.J. Oliveira, A.M. Urbano
\nBiochimica et Biophysica Acta (BBA) \u2013 Molecular Basis of Disease 1867(2)<\/strong>, 166031\u2013166031 (2021)<\/p>\n

Otto Warburg: The journey towards the seminal discovery of tumor cell bioenergetic reprogramming<\/a>
\nA.M. Urbano
\nBiochimica et Biophysica Acta (BBA) \u2013 Molecular Basis of Disease 1867(1)<\/strong>, 165965\u2013165965 (2021)<\/p>\n

Intermediary metabolism: An intricate network at the crossroads of cell fate and function<\/a>
\nL.M.R. Ferreira, A.M. Li, T.L. Serafim, M.C. Sobral, M.C. Alpoim, A.M. Urbano
\nBiochimica et Biophysica Acta (BBA) \u2013 Molecular Basis of Disease 1866(10)<\/strong>, 165887\u2013165887 (2020)<\/p>\n

Impact of Carcinogenic Chromium on the Cellular Response to Proteotoxic Stress<\/a>
\nL.M.R. Ferreira, T. Cunha-Oliveira, M.C. Sobral, P.L. Abreu, M.C. Alpoim, A.M. Urbano
\nInternational Journal of Molecular Sciences 20(19)<\/strong>, 4901 (2019)<\/p>\n

Hexavalent chromium, a lung carcinogen, confers resistance to thermal stress and interferes with heat shock protein expression in human bronchial epithelial cells<\/a>
\nP.L. Abreu, T. Cunha-Oliveira, L.M.R. Ferreira, A.M. Urbano
\nBioMetals 31(4)<\/strong>, 477\u2013487 (2018)<\/p>\n

Impact of the culturing conditions and culture age on the growth characteristics and genomic stability of BEAS-2B cells<\/a>
\nP.L. Abreu, D.C. Ferreira, A.F. Laranjeiro, A. Mascarenhas, C. Pais, J.B. Melo, I.M. Carreira, A.M. Urbano
\nFree Radical Biology and Medicine 120(S1)<\/strong>, S93\u2013S93 (2018)<\/p>\n

Photophysical Characterization and in vitro\u00a0Phototoxicity Evaluation of 5,10,15,20-tetra-(quinolin-2-yl)-porphyrin as a Potential Sensitizer for Photodynamic Therapy<\/a>
\nL.D. Costa, J.A. Silva, S.M. Fonseca, C.T. Arranja, A.M. Urbano, A.J.F.N. Sobral
\nMolecules 21(4)<\/strong>, 439 (2016)<\/p>\n

Targeting the Warburg Effect for Cancer Therapy: A Long and Winding Road
\nP.L. Abreu, A.M. Urbano
\nAtta-ur-Rahman (Ed.),\u00a0 In “Frontiers in Clinical Drug Research – Anti-Cancer Agents” , Bentham Science Publishers, volume 3, cap.4 (2016)<\/p>\n

Short-term Exposure of Nontumorigenic Human Bronchial Epithelial Cells to Carcinogenic Chromium(VI) Compromises Their Respiratory Capacity and Alters Their Bioenergetic Signature<\/a>
\nJ.F. Cerveira, M. Sanch\u00e9z-Arag\u00f3, A.M. Urbano, J.M. Cuezva
\nFEBS Open Bio 4<\/strong>, 594\u2013601 (2014)<\/p>\n

Impact of Hexavalent Chromium on Mammalian Cell Bioenergetics: Phenotypic Changes, Molecular Basis and Potential Relevance to Chromate-Induced Lung Cancer<\/a>
\nP.L. Abreu, L.M.R. Ferreira, M.C. Alpoim, A.M. Urbano
\nBioMetals\u00a027(3)<\/b>, 409-443 (2014)<\/p>\n

Effects of Hexavalent Chromium [Cr(VI)] on the Stress Response of a Human Bronchial Epithelial Cell Line
\nA.M. Urbano, L.M.R. Ferreira, P.L. Abreu
\nRevista Portuguesa de Pneumologia\u00a020(Esp Cong 2)<\/b>, 8-21 (2014)<\/p>\n

Exposure of Human Bronchial Epithelial Cells to Hexavalent Chromium [Cr(VI)] Decreases the Expression of Heat Shock Protein 90 alpha (Hsp90\u03b1) and Attenuates the Transient Growth Arrest Induced by an Acute Cold Shock<\/a>
\nA.M. Urbano, L.M.R. Ferreira, P.L. Abreu
\nFEBS Journal\u00a0280(S1)<\/b>, 239 (2013)<\/p>\n

Molecular and Cellular Mechanisms of Hexavalent Chromium-Induced Lung Cancer: An Updated Perspective<\/a>
\nA. M. Urbano, L. M. R. Ferreira, M. C. Alpoim
\nCurrent Drug Metabolism\u00a013(3)<\/b>, 284\u2013305 (2012)<\/p>\n

Changes in Glucose Uptake Rate and in the Energy Status of PC-12 Cells Acutely Exposed to Hexavalent Chromium, an Established Human Carcinogen<\/a>
\nM.J. Gon\u00e7alves, A.C.C. Santos, P. Coelho, A.N. Costa, C.F.D. Rodrigues, M.S. Santos, A.J. Guiomar, M.C. Alpoim, A.M. Urbano
\nToxicological & Environmental Chemistry\u00a093(6)<\/b>, 1202-1211 (2011)<\/p>\n

Malignant Transformation of Human Bronchial Epithelial Cells (BEAS-2B) by Cr(VI) is Associated with Altered Mitochondria and Bioenergetic Phenotype<\/a>
\nA. Sampaio A, L. Mendes, A. C. Gon\u00e7alves, M Abrantes M, A. B. Sarmento, F. Botelho, P. Oliveira, R. Carvalho R, A. Urbano, M. C. Alpoim
\nFEBS Journal\u00a0277<\/b>, 224 (2010)<\/p>\n

Induction of Morphological Changes in BEAS-2B Human Bronchial Epithelial Cells Following Chronic Sub-Cytotoxic and Mildly Cytotoxic Hexavalent Chromium Exposures<\/a>
\nA.N. Costa, V. Moreno, M.J. Prieto, A.M. Urbano and M.C. Alpoim
\nMolecular Carcinogenesis\u00a049(6)<\/b>, 582\u2013591 (2010)<\/p>\n

Cr(VI)-Induced Malignant Transformation of a Bronchial Epithelial Cell Line Association with Altered Mitochondria and Bioenergetic Phenotypes<\/a>
\nA. Sampaio A, L. Mendes, A. C. Gon\u00e7alves, M Abrantes M, A. B. Sarmento, F. Botelho, P. Oliveira, R. Carvalho R, A. Urbano, M. C. Alpoim
\nBMC Proceedings 4(Suppl 2)<\/strong>, 17 (2010)<\/p>\n

Changes in the Energy Status and Glucose Uptake Rate of PC-12 Cells Induced by Acute Subcytotoxic or Mildly Cytotoxic Hexavalent Chromium Insults<\/a>
\nM.J. Gon\u00e7alves, A.C.C. Santos, P. Coelho, A.N. Costa, C.F.D. Rodrigues, M.S. Santos, A.J. Guiomar, M.C. Alpoim, A.M. Urbano
\nFEBS Journal\u00a0277<\/b>, 70 (2010)<\/p>\n

A New Nonconjugated Naphthalene Derivative of Meso-tetra-(3-hydroxy)-phenyl-porphyrin as a Potential Sensitizer for Photodynamic Therapy<\/a>
\nP. Silva, S.M. Fonseca, C.T. Arranja, H.D. Burrows, A.M. Urbano, A.J.F.N. Sobral
\nPhotochemistry and Photobiology\u00a086(5)<\/b>, 1147\u20131153 (2010)<\/p>\n

Hexavalent Chromium and Lung Cancer: New Perspectives
\nC.F.D. Rodrigues, A. Almeida, I.M. Carreira, E. Matoso, A.M. Urbano, M.F. Botelho, L. Carvalho, M. Alves, C. Monteiro, M.C. Alpoim
\nFEBS Journal,\u00a0276<\/b>, 339 (2009)<\/p>\n

Human Bronchial Epithelial Cells Malignantly Transformed By Hexavalent Chromium Exhibit An Aneuploid Phenotype But No Microsatellite Instability<\/a>
\nC.F.D. Rodrigues, A.M. Urbano, E. Matoso, I. Carreira, A. Almeida, P. Santos, F. Botelho, L. Carvalho, M. Alves, C. Monteiro, A.N. Costa, V. Moreno and M.C. Alpoim
\nMutation Research – Fundamental and Molecular Mechanisms of Mutagenesis\u00a0670(1-2)<\/b>, 42-52 (2009)<\/p>\n

Crystal structure of 2,5-dimethyl-1-(4-carboxyphenyl)pyrrole, C13<\/sub>H13<\/sub>NO2<\/sub><\/a>
\nM.R. Silva, J.A. Silva, A.M. Urbano, A.C. Santos, A.J.F.N. Sobral, A.M. Beja and J.A. Paix\u00e3o
\nZeitschrift f\u00fcr Kristallographie – New Crystal Structures\u00a0223(1)<\/b>, 33-34 (2008)<\/p>\n

Hexavalent Chromium Exposure, Genomic Instability and Lung Cancer
\nA.M. Urbano, C.F.D. Rodrigues and M.C. Alpoim
\nGene Therapy and Molecular Biology\u00a012<\/b>, 219-238 (2008)<\/p>\n

Clastogenic effects of hexavalent chromium in a human bronchial epithelial cell line
\nC.F. Rodrigues, A.M. Urbano, E. Matoso, I.M. Carreira, M.C. Alpoim
\nFEBS Journal\u00a0275<\/b>, 114 (2008)<\/p>\n

Effect of the Metal Center on the Antitumor Activity of the Analogous Dinuclear Spermine Chelates (PdCl2)(2)(Spermine) and (PtCl2)(2)(Spermine)
\nA.S. Soares, S.M. Fiuza, M.J. Goncalves, L.A.E. Batista de Carvalho, M.P.M. Marques, A.M. Urbano
\nLetters in Drug Design & Discovery\u00a04<\/b>, 460-463 (2007)<\/p>\n","protected":false},"excerpt":{"rendered":"

Ana Margarida Urbano received a PhD in Biochemistry from the Universiy of Cambridge, UK. She is an assistant professor at the Department of Life Sciences of the\u00a0University of Coimbra, Portugal. Her main research interests are bioenergetics, oncometabolism and inorganic biochemistry and she is currently investigating the molecular basis of Cr(VI)-induced carcinogenesis. Address Departamento de Ci\u00eancias […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-545","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/pages\/545","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/comments?post=545"}],"version-history":[{"count":4,"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/pages\/545\/revisions"}],"predecessor-version":[{"id":4679,"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/pages\/545\/revisions\/4679"}],"wp:attachment":[{"href":"https:\/\/qfm.uc.pt\/index.html\/wp-json\/wp\/v2\/media?parent=545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}