Ana Margarida Urbano é doutorada em Bioquímica pela Universidade de Cambridge (Reino Unido), é Professora Auxiliar da Universidade de Coimbra, a desempenhar funções docentes no Departamento de Ciências da Vida (Faculdade de Ciências e Tecnologia). Os seus principais interesses científicos inserem-se nas áreas da bioenergética, oncometabolismo e bioquímica inorgânica, encontrando, actualmente, a estudar os mecanismos moleculares subjacentes à acção cancerígena do crómio no estado hexavalente.
| Endereço Departamento de Ciências da Vida Faculdade de Ciências e Tecnologia Universidade de Coimbra Calçada Martim de Freitas 3000-456 Coimbra |
E-mail amurbano@uc.pt Telefone +351 239 240 707 |
ORCID ID ResearcherID Scopus ID Curriculum Vitae |
Publicações
Polyhexanide-Releasing Membranes for Antimicrobial Wound Dressings: A Critical Review
A.J. Guiomar, A.M. Urbano
Membranes 12(12), 1281 (2022)
Effect of exercise-conditioned human serum on the viability of cancer cell cultures: a systematic review and meta-analysis
C.M. Soares, A.M. Teixeira, H. Sarmento, F.M. Silva, M.C. Rusenhack, M. Furmann, P.R. Nobre, M.A. Fachada, A.M. Urbano, J.P. Ferreira
Exercise Immunology Review 27, 24–41 (2021)
Oncometabolism: The switchboard of cancer – An editorial
P.J. Oliveira, A.M. Urbano
Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease 1867(2), 166031–166031 (2021)
Otto Warburg: The journey towards the seminal discovery of tumor cell bioenergetic reprogramming
A.M. Urbano
Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease 1867(1), 165965–165965 (2021)
Intermediary metabolism: An intricate network at the crossroads of cell fate and function
L.M.R. Ferreira, A.M. Li, T.L. Serafim, M.C. Sobral, M.C. Alpoim, A.M. Urbano
Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease 1866(10), 165887–165887 (2020)
Impact of Carcinogenic Chromium on the Cellular Response to Proteotoxic Stress
L.M.R. Ferreira, T. Cunha-Oliveira, M.C. Sobral, P.L. Abreu, M.C. Alpoim, A.M. Urbano
International Journal of Molecular Sciences 20(19), 4901 (2019)
Hexavalent chromium, a lung carcinogen, confers resistance to thermal stress and interferes with heat shock protein expression in human bronchial epithelial cells
P.L. Abreu, T. Cunha-Oliveira, L.M.R. Ferreira, A.M. Urbano
BioMetals 31(4), 477–487 (2018)
Impact of the culturing conditions and culture age on the growth characteristics and genomic stability of BEAS-2B cells
P.L. Abreu, D.C. Ferreira, A.F. Laranjeiro, A. Mascarenhas, C. Pais, J.B. Melo, I.M. Carreira, A.M. Urbano
Free Radical Biology and Medicine 120(S1), S93–S93 (2018)
Photophysical Characterization and in vitro Phototoxicity Evaluation of 5,10,15,20-tetra-(quinolin-2-yl)-porphyrin as a Potential Sensitizer for Photodynamic Therapy
L.D. Costa, J.A. Silva, S.M. Fonseca, C.T. Arranja, A.M. Urbano, A.J.F.N. Sobral
Molecules 21(4), 439 (2016)
Targeting the Warburg Effect for Cancer Therapy: A Long and Winding Road
P.L. Abreu, A.M. Urbano
Atta-ur-Rahman (Ed.), In “Frontiers in Clinical Drug Research – Anti-Cancer Agents” , Bentham Science Publishers, volume 3, cap.4 (2016)
Short-term Exposure of Nontumorigenic Human Bronchial Epithelial Cells to Carcinogenic Chromium(VI) Compromises Their Respiratory Capacity and Alters Their Bioenergetic Signature
J.F. Cerveira, M. Sanchéz-Aragó, A.M. Urbano, J.M. Cuezva
FEBS Open Bio 4, 594–601 (2014)
Impact of Hexavalent Chromium on Mammalian Cell Bioenergetics: Phenotypic Changes, Molecular Basis and Potential Relevance to Chromate-Induced Lung Cancer
P.L. Abreu, L.M.R. Ferreira, M.C. Alpoim, A.M. Urbano
BioMetals 27(3), 409-443 (2014)
Effects of Hexavalent Chromium [Cr(VI)] on the Stress Response of a Human Bronchial Epithelial Cell Line
A.M. Urbano, L.M.R. Ferreira, P.L. Abreu
Revista Portuguesa de Pneumologia 20(Esp Cong 2), 8-21 (2014)
Exposure of Human Bronchial Epithelial Cells to Hexavalent Chromium [Cr(VI)] Decreases the Expression of Heat Shock Protein 90 alpha (Hsp90α) and Attenuates the Transient Growth Arrest Induced by an Acute Cold Shock
A.M. Urbano, L.M.R. Ferreira, P.L. Abreu
FEBS Journal 280(S1), 239 (2013)
Molecular and Cellular Mechanisms of Hexavalent Chromium-Induced Lung Cancer: An Updated Perspective
A. M. Urbano, L. M. R. Ferreira, M. C. Alpoim
Current Drug Metabolism 13(3), 284–305 (2012)
Changes in Glucose Uptake Rate and in the Energy Status of PC-12 Cells Acutely Exposed to Hexavalent Chromium, an Established Human Carcinogen
M.J. Gonçalves, A.C.C. Santos, P. Coelho, A.N. Costa, C.F.D. Rodrigues, M.S. Santos, A.J. Guiomar, M.C. Alpoim, A.M. Urbano
Toxicological & Environmental Chemistry 93(6), 1202-1211 (2011)
Malignant Transformation of Human Bronchial Epithelial Cells (BEAS-2B) by Cr(VI) is Associated with Altered Mitochondria and Bioenergetic Phenotype
A. Sampaio A, L. Mendes, A. C. Gonçalves, M Abrantes M, A. B. Sarmento, F. Botelho, P. Oliveira, R. Carvalho R, A. Urbano, M. C. Alpoim
FEBS Journal 277, 224 (2010)
Induction of Morphological Changes in BEAS-2B Human Bronchial Epithelial Cells Following Chronic Sub-Cytotoxic and Mildly Cytotoxic Hexavalent Chromium Exposures
A.N. Costa, V. Moreno, M.J. Prieto, A.M. Urbano and M.C. Alpoim
Molecular Carcinogenesis 49(6), 582–591 (2010)
Cr(VI)-Induced Malignant Transformation of a Bronchial Epithelial Cell Line Association with Altered Mitochondria and Bioenergetic Phenotypes
A. Sampaio A, L. Mendes, A. C. Gonçalves, M Abrantes M, A. B. Sarmento, F. Botelho, P. Oliveira, R. Carvalho R, A. Urbano, M. C. Alpoim
BMC Proceedings 4(Suppl 2), 17 (2010)
Changes in the Energy Status and Glucose Uptake Rate of PC-12 Cells Induced by Acute Subcytotoxic or Mildly Cytotoxic Hexavalent Chromium Insults
M.J. Gonçalves, A.C.C. Santos, P. Coelho, A.N. Costa, C.F.D. Rodrigues, M.S. Santos, A.J. Guiomar, M.C. Alpoim, A.M. Urbano
FEBS Journal 277, 70 (2010)
A New Nonconjugated Naphthalene Derivative of Meso-tetra-(3-hydroxy)-phenyl-porphyrin as a Potential Sensitizer for Photodynamic Therapy
P. Silva, S.M. Fonseca, C.T. Arranja, H.D. Burrows, A.M. Urbano, A.J.F.N. Sobral
Photochemistry and Photobiology 86(5), 1147–1153 (2010)
Hexavalent Chromium and Lung Cancer: New Perspectives
C.F.D. Rodrigues, A. Almeida, I.M. Carreira, E. Matoso, A.M. Urbano, M.F. Botelho, L. Carvalho, M. Alves, C. Monteiro, M.C. Alpoim
FEBS Journal, 276, 339 (2009)
Human Bronchial Epithelial Cells Malignantly Transformed By Hexavalent Chromium Exhibit An Aneuploid Phenotype But No Microsatellite Instability
C.F.D. Rodrigues, A.M. Urbano, E. Matoso, I. Carreira, A. Almeida, P. Santos, F. Botelho, L. Carvalho, M. Alves, C. Monteiro, A.N. Costa, V. Moreno and M.C. Alpoim
Mutation Research – Fundamental and Molecular Mechanisms of Mutagenesis 670(1-2), 42-52 (2009)
Crystal structure of 2,5-dimethyl-1-(4-carboxyphenyl)pyrrole, C13H13NO2
M.R. Silva, J.A. Silva, A.M. Urbano, A.C. Santos, A.J.F.N. Sobral, A.M. Beja and J.A. Paixão
Zeitschrift für Kristallographie – New Crystal Structures 223(1), 33-34 (2008)
Hexavalent Chromium Exposure, Genomic Instability and Lung Cancer
A.M. Urbano, C.F.D. Rodrigues and M.C. Alpoim
Gene Therapy and Molecular Biology 12, 219-238 (2008)
Clastogenic effects of hexavalent chromium in a human bronchial epithelial cell line
C.F. Rodrigues, A.M. Urbano, E. Matoso, I.M. Carreira, M.C. Alpoim
FEBS Journal 275, 114 (2008)
Effect of the Metal Center on the Antitumor Activity of the Analogous Dinuclear Spermine Chelates (PdCl2)(2)(Spermine) and (PtCl2)(2)(Spermine)
A.S. Soares, S.M. Fiuza, M.J. Goncalves, L.A.E. Batista de Carvalho, M.P.M. Marques, A.M. Urbano
Letters in Drug Design & Discovery 4, 460-463 (2007)