Ana Batista de Carvalho é investigadora na Unidade de I&D Química-Física Molecular. Dedica a sua actividade de investigação no estudo experimental (espectroscopia vibracional) de compostos de platina e paládio e compostos fenólicos com potencial actividade anticancerígena e antioxidante.
| Endereço Departamento de Química Faculdade de Ciências e Tecnologia Universidade de Coimbra 3004-535 Coimbra |
E-mail almbc@uc.pt Telefone +351 239 852 084 |
ORCID ID ResearcherID Scopus ID ResearchGate Ciência Vitae |
Publicações
Synchrotron Nano-FTIR Spectroscopy for Probing Anticancer Drugs at Subcellular Scale
L.A.E. Batista de Carvalho, G. Cinque, A.L.M. Batista de Carvalho, J.Marques, M.D.Fogley, H. Vondracek, M.P.M. Marques
Scientific Reports 14, 17166 (2024)
Vibrational microspectroscopy as a tool to unveil new chemotherapeutic strategies against osteosarcoma
R.C. Laginha, J.D. Silva, G. Cinque, L.A.E. Batista de Carvalho, A.L.M. Batista de Carvalho
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (2024)
Pd2Spermine as an Alternative Therapeutics for Cisplatin-Resistant Triple-Negative Breast Cancer
T.J. Carneiro, A.L.M. Batista de Carvalho, M. Vojtek, R.C. Laginha, M.P.M. Marques, C. Diniz, A.M. Gil
Journal of Medicinal Chemistry (2024)
Cervical Squamous Cell Carcinoma Diagnosis by FTIR Microspectroscopy
M.M. Félix, M.V. Tavares, I.P. Santos, A.L.M. Batista de Carvalho, L.A.E. Batista de Carvalho, M.P.M. Marques
Molecules 29, 922 (2024)
Cellular Dynamics as a Marker of Normal-to-Cancer Transition in Human Cells
M.P.M. Marques, A.L.M. Batista de Carvalho, C.B. Martins, J.D. Silva, M. Sarter, V. García Sakai, R. Stewart, L.A.E. Batista de Carvalho
Scientific Reports 13, 21709 (2023)
Disclosing a Metabolic Signature of Cisplatin Resistance in MDA-MB-231 Triple-Negative Breast Cancer Cells by NMR Metabolomics
T.J. Carneiro, A.L.M. Batista de Carvalho, M. Vojtek, I.F. Carmo, M.P.M. Marques, C. Diniz, A.M. Gil
Cancer Cell International 23, 310 (2023)
Fluorinated Mn(III)/(II)-Porphyrin with Redox-Responsive 1H and 19F Relaxation Properties
S.M.A. Pinto, A.R.R. Ferreira, D.S.S. Teixeira, S.C.C. Nunes, A.L.M. Batista de Carvalho, J.M.S. Almeida, Z. Garda, A. Pallier, A.A.C.C. Pais, C.M.A. Brett, E. Tóth, M.P.M. Marques, M.M. Pereira, C.F.G.C. Geraldes
Chemistry – A European Journal 2023, e202301442 (2023)
Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Activity Towards TNBC-sensitive and -resistant to Cisplatin
M. Vojtek, C.B. Martins, R. Ramos, S.G. Duarte, I.M.P.L.V.O. Ferreira, A.L.M. Batista de Carvalho, M.P.M. Marques, C. Diniz
Pharmaceutics – Special Issue “Beyond the Platinum in Metal-Based Cancer Therapy II” 15, 1205 (2023)
A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line
J.D. Silva, J. Marques, I.P. Santos, A.L.M. Batista de Carvalho, C.B. Martins, R.C. Laginha, L.A.E. Batista de Carvalho, M.P.M. Marques
Molecules 28(4), 1698 (2023)
Evaluation of the Cytotoxic Effect of Pd2Spm against Prostate Cancer through Vibrational Microspectroscopies
R.C. Laginha, C.B. Martins, A.L.C. Brandão, J. Marques, M.P.M. Marques, L.A.E. Batista de Carvalho, I.P. Santos, A.L.M. Batista de Carvalho
International Journal of Molecular Sciences 24(3), 1888 (2023)
Effect of Pd2Spermine on Mice Brain-Liver Axis Metabolism Assessed by NMR Metabolomics
T.J. Carneiro, M. Vojtek, S. Gonçalves-Martins, A.L.M. Batista de Carvalho, M.P.M. Marques, C. Diniz, A.M. Gil
International Journal of Molecular Sciences 23(22), 13773 (2022)
Breast Cancer or Surrounding Normal Tissue? A Successful Discrimination by FTIR and Raman Microspectroscopies
A.P. Mamede, I.P. Santos, A.L.M. Batista de Carvalho, P. Figueiredo, M.C. Silva, M.P.M. Marques, L.A.E. Batista de Carvalho
Analyst 147(21), 4919–4932 (2022)
Water Dynamics in Human Cancer and Non-Cancer Tissues
M.P.M. Marques, I.P. Santos, A.L.M. Batista de Carvalho, A.P. Mamede, C.B. Martins, P. Figueiredo, M. Sarter, V. Garcia Sakai, L.A.E. Batista de Carvalho
Physical Chemistry Chemical Physics 24(25), 15406–15415 (2022)
Metabolic Impact of Anticancer Drugs Pd2Spermine and Cisplatin on the Brain of Healthy Mice
T.J. Carneiro, M. Vojtek, S. Gonçalves-Monteiro, J.R. Neves, A.L.M. Batista de Carvalho, M.P.M. Marques, C. Diniz, A.M. Gil
Pharmaceutics 14(2), 259 (2022)
Pd2Spermine Complex Shows Cancer Selectivity and Efficacy to Inhibit Growth of Triple-Negative Breast Tumors in Mice
M. Vojtek, S. Gonçalves-Monteiro, P. Seminska, K. Valova, L. Bellón, P. Dias-Pereira, F. Marques, M.P.M. Marques, A.L.M. Batista de Carvalho, H. Mota-Filipe, I.M.P.L.V.O. Ferreira, C. Diniz
Biomedicines 10(2), 210 (2022)
Who’s who? Discrimination of Human Breast Cancer Cell Lines by Raman and FTIR Microspectroscopy
I.P. Santos, C.B. Martins, L.A.E. Batista de Carvalho, M.P.M. Marques, A.L.M. Batista de Carvalho
Cancers – Special Issue Biophotonics and Imaging for Cancer Screening, Diagnosis, and Treatment Monitoring 14(2), 452 (2022)
Palladium-Spermine Complex (Pd2Spm) Triggers Autophagy and Caspase-Independent Cell Death in Triple-Negative Breast Cancer Cells
M. Vojtek, M.P.M. Marques, A.L.M. Batista de Carvalho, H. Mota-Filipe, I.M. Ferreira, C. Diniz
Cancer Cells. In Medical Sciences Forum 14(1), 142 (2022)
A New Look into Cancer – A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance
A.P. Mamede, I.P. Santos, A.L.M. Batista de Carvalho, P. Figueiredo, M.C. Silva, M.V. Tavares, M.P.M. Marques, L.A.E. Batista de Carvalho
Cancers – Special Issue Biophotonics and Imaging for Cancer Screening, Diagnosis, and Treatment Monitoring 13(21), 5336 (2021)
Novel Insights into Mice Multi-organ Metabolism upon Exposure to a Potential Anticancer Pd(II)-Agent
T.J. Carneiro, R. Araújo, M. Vojtek, S. Gonçalves-Monteiro, C. Diniz, A.L.M. Batista de Carvalho, M.P.M. Marques, A.M. Gil
Metabolites- Special Issue – Metabolomics in Drug Discovery and Development 11(2), 114 (2021)
Preclinical Pharmacokinetics and Biodistribution of Anticancer Dinuclear Palladium(II)-Spermine Complex (Pd2Spm) in Mice
M. Vojtek, S. Gonçalves-Monteiro, E. Pinto, S. Kalivodová, A. Almeida, M.P.M. Marques, A.L.M. Batista de Carvalho, C.B. Martins, H. Mota-Filipe, I.M.P.L.V.O Ferreira, C. Diniz
Pharmaceuticals 14(2), 173 (2021)
Metallodrug–Protein Interaction Probed by Synchrotron Terahertz and Neutron Scattering Spectroscopy
L.A.E. Batista de Carvalho, A.P. Mamede, A.L.M. Batista de Carvalho*, J. Marques, G. Cinque, S. Rudić, M.P.M. Marques
Biophysical Journal 120(15), 3070–3078 (2021)
Response of Osteosarcoma Cell Metabolism to Platinum and Palladium Chelates as Potential New Drugs
A.S. Martins, A.L.M. Batista de Carvalho, M.P.M. Marques, A.M. Gil
Molecules 26(16), 4805 (2021)
Re-use of Caco-2 Monolayers in Permeability Assays – Validation Regarding Cell Monolayer Integrity
C.L. Pires, C. Praça, P.A.T. Martins, A.L.M. Batista de Carvalho, L. Ferreira, M.P.M. Marques, M.J. Moreno
Pharmaceutics 13(10), 1563 (2021)
Impact of Pd2Spm(spermine) Complex on the Metabolism of Triple-negative Breast Cancer Tumors of a Xenograft Mouse Model
T.J. Carneiro, R. Araújo, M. Vojtek, S.G. Monteiro, C. Diniz, A.L.M. Batista de Carvalho, M.P.M. Marques, A.M. Gil
International Journal of Molecular Sciences 22(19), 10775 (2021)
Intracellular Water as a Mediator of Anticancer Drug Action
M.P.M. Marques, A.L.M. Batista de Carvalho, A.P Mamede, S. Rudic, A. Dopplapudi, V. García Sakai e L.A.E. Batista de Carvalho
International Reviews in Physical Chemistry 39(1), 67–81 (2020)
Role of intracellular water in the normal-to-cancer transition in human cells – insights from quasi-elastic neutron scattering
M.P.M. Marques, A.L.M. Batista de Carvalho, A.P. Mamede, A. Dopplapudi, V. García Sakai, L.A.E. Batista de Carvalho
Structural Dynamics 7(5), 054701 (2020)
A New Look into the Mode of Action of Metal-Based Anticancer Drugs
M.P.M. Marques, A.L.M. Batista de Carvalho, A.P. Mamede, A. Dopplapudi, S. Rudić, M. Tyagi, V. García Sakai, L.A.E. Batista de Carvalho
Molecules 25(2), 246 (2020)
Cytotoxicity of Platinum and Palladium Chelates Against Osteosarcoma
A.S. Martins, A.L.M. Batista de Carvalho, I. Lamego, M.P.M. Marques, A.M. Gil
ChemistrySelect 5(20), 5993–6000 (2020)
Multi-organ NMR Metabolomics to Assess In Vivo Overall Metabolic Impact of Cisplatin in Mice
T.J. Carneiro, R. Araújo, M. Vojtek, S. Gonçalves-Monteiro, C. Diniz, A.L.M. Batista de Carvalho, M.P.M. Marques, A.M. Gil
Metabolites 9(11), 279 (2019)
Chemotherapeutic Targets in Osteosarcoma Insights from Synchrotron-MicroFTIR and Quasi-Elastic Neutron Scattering
M.P.M. Marques, A.L.M. Batista de Carvalho, A.P. Mamede, I.P. Santos, V. García-Sakai, A. Dopplapudi, G. Cinque, M. Wolna, P. Gardner, L.A.E. Batista de Carvalho
The Journal of Physical Chemistry B 123, 6968–6979 (2019)
Bioinspired-Metalloporphyrin Magnetic Nanocomposite as a Reusable Catalyst for Synthesis of Diastereomeric (-)-isopulegol Epoxide. Anticancer Activity Against Human Osteosarcoma Cells (MG-63)
L.D. Dias, A.L.M. Batista de Carvalho, S.M.A. Pinto, G.L.B. Aquino, M.J.F. Calvete, L.M. Rossi, M.P.M. Marques, M.M. Pereira
Molecules 24(1), 52 (2019)
Anticancer Drug Impact on DNA – A Study by Neutron Spectroscopy coupled to Synchrotron-based FTIR and EXAFS
A.L.M. Batista de Carvalho, A.P. Mamede, A. Dopplapudi, V. Garcia Sakai, J. Doherty, M. Frogley, G. Cinque, P. Gardner, D. Gianolio, L.A.E. Batista de Carvalho, M.P.M. Marques
Physical chemistry Chemical Physics 21(8), 4162–4175 (2019)
A Novel Approach in Glioblastoma Multiforme Drug Discovery: Perturbation Studies in Vitro
L.C. Oliveira, M.P.M. Marques, A.J. Caseiro, S. R. Raposelli, A.L.M. Batista de Carvalho, A.P. Fonseca
Journal of Applied Pharmaceutical Science 9(4), 58–65 (2019)
The Impact of Antioxidants from the Diet on Breast Cancer Cells Monitored by Raman Microspectroscopy
P.S.C. Medeiros, A.L.M. Batista de Carvalho, C. Ruano, J.C. Otero, M.P.M. Marques
Letters in Drug Design & Discovery 16(2), 127–137 (2018)
Novel Platinum-based Anticancer Drug: a Complete Vibrational Study
A.L.M. Batista de Carvalho, S.F. Parker, L.A.E Batista de Carvalho, M.P.M. Marques
Acta Chrystallographica Section C – Structural Chemistry C74, 628–634 (2018)
Antiproliferative Activity of Olive Oil Phenolics Against Human Melanoma Cells
A.L.M. Batista de Carvalho, F. Caselli, V. Rodrigues, F. Paiva-Martins, M.P.M. Marques
Letters in Drug Design & Discovery 14, 1–7 (2017)
Intracellular Water – an Overlooked Drug Target? Cisplatin´s Impact in Cancer Cells Probed by Neutrons
M.P.M. Marques, A.L.M. Batista de Carvalho, V. Garcia-Sakai, L. Hatter, L.A.E. Batista de Carvalho
Physical Chemistry Chemical Physics 19, 2702–2713 (2017)
Anti-invasive and Anti-proliferative Synergism Between Docetaxel and a Polynuclear Pd-Spermine Agent
A.L.M. Batista de Carvalho, P.S.C. Medeiros, F.M. Costa, V.P. Ribeiro, J.B. Sousa, C. Diniz, M.P.M. Marques
PLoS ONE 11, e0167218 (2016)
Raman Microspectroscopy for Probing the Impact of a Dietary Antioxidant on Human Breast Cancer Cells
P.S.C. Medeiros, A.L.M. Batista de Carvalho, C. Ruano, J.C. Otero, M.P.M. Marques
Food&Function 7, 2800–2810 (2016)
Chemotherapeutic Response to Cisplatin-like Drugs in Human Breast Cancer Cells Probed by Vibrational Microspectroscopy
A.L.M. Batista de Carvalho, M. Pilling, P. Gardner, J. Doherty, G. Cinque, K. Wehbe, C. Kelley, L.A.E. Batista de Carvalho, M.P.M. Marques
Faraday Discussions 187, 273–298 (2016)
In Vitro Probing of Human Refractory Prostate Cancer Cells by MicroRaman Spectroscopy
A.L.M. Batista de Carvalho, C.R. Frias, J.C. Otero, M.P.M. Marques
FEBS Journal 280(S1), 311 (2013)
New Strategies Against Prostate Cancer – Pt(II)-Based Chemotherapy
C.S. Matos, A.L.M. Batista de Carvalho, R. Pedro Lopes e M.P.M. Marques
Current Medicinal Chemistry 19(27), 4678–4687 (2012)
Pt(II) Complexes with Linear Diamines — Part I: Vibrational Study of Pt-Diaminopropane
A.L.M. Batista de Carvalho, S.M. Fiuza, J. Tomkinson, L.A.E. Batista de Carvalho, M.P.M. Marques
Spectroscopy: An International Journal 27(5-6), 403–413 (2012)